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News and views on EMT Fra-1 controls EMT in mammary epithelial cells

Epithelial-to-mesenchymal transition (EMT) is a complex biological program occurring in physiological and pathological conditions. The acquisition of a mesenchymal state by cancer cells is associated with loss of epithelial features, decreased cell adhesion and increased migration and invasion, which together are crucial for metastasis. Down-regulation of the adherens junction protein E-cadheri...

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Cholesterol sulfate stimulates involucrin transcription in keratinocytes by increasing Fra-1, Fra-2, and Jun D.

Lipids that are synthesized de novo in the epidermis, including fatty acids, oxysterols, 1,25-dihydroxyvitamin D(3), and farnesol, can regulate the differentiation of normal human keratinocytes (NHK). Cholesterol sulfate (CS), an epidermal lipid that is produced in the upper nucleated layers of the epidermis coincident with terminal differentiation, has been shown to play a role in the regulati...

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